There is no single best treatment. The plan depends on size, thickness, site, whether cartilage is involved, and how the lesion responded to anything tried before.
Intralesional corticosteroid injection is first-line for most small-to-moderate keloids and the mainstay of treatment here. Dilute triamcinolone is injected into the lesion to suppress the fibroblasts driving growth, slow new collagen production, and speed breakdown of the collagen already laid down. Sessions typically run every four to six weeks, commonly three to six of them, and softening usually arrives before visible flattening. The recognised side effects are hypopigmentation, which can be long-lasting and is more noticeable on deeper skin tones; thinning of skin and fat that can leave a small depression; visible fine vessels at the site; and occasional ulceration. That is why dosing is kept conservative.
5-fluorouracil and bleomycin are the usual second injectable lines when a steroid course stalls — 5-fluorouracil, alone or mixed with triamcinolone, more often than bleomycin. Both are used off-label for keloids, on a smaller evidence base than steroid. Injection pain, ulceration, and hyperpigmentation are recognised effects, and bleomycin can cause dermal necrosis and a streaky pigmentation pattern. Neither is offered in pregnancy or while breastfeeding, and bleomycin is avoided on the fingers and toes.
Surgical excision is for bulky or stalked keloids and lesions injections cannot flatten, and is always planned with a post-operative injection series rather than performed on its own.
Two things are worth stating plainly, because patients ask about both by name. Cryotherapy and laser are not part of the course offered at this clinic — the plan here is injection-led, with excision where the lesion needs it. Superficial radiotherapy is a specialist, last-line adjuvant, referred out to a radiation oncology unit rather than delivered here. It is reserved for resistant or repeatedly recurrent lesions because of the small long-term risk from irradiating normal skin, and is not used in children or in pregnancy.
Which rung a particular keloid starts on is decided at examination, and the grouping below is roughly how cases sort out in practice.